Although rare cancers don’t occur often, they can affect people of all ages and genders. Greater awareness of rare cancers may lead to earlier diagnosis and management, and potentially better survival rates. Consider these facts about soft tissue sarcomas, one type of rare cancer.
Understanding Rare Cancers
Four facts to know about one type of rare cancer, soft tissue sarcomas
(Family Features) Although rare cancers don’t occur often, they can affect people of all ages and genders.
A rare cancer is defined as fewer than 15 new diagnoses per 100,000 people per year, according to the National Cancer Institute (NCI). Additionally, as noted by the American Cancer Society (ACS), the 5-year survival rate is lower for people diagnosed with a rare cancer than for people living with more common cancers. Greater awareness of rare cancers may lead to earlier diagnosis and management, and potentially better survival rates.
If you have recently been diagnosed with STS, it’s important to ask your doctor for more information about the specific sub-type you have. For example, if you received a diagnosis of undifferentiated sarcoma, ask your doctor for an integrase interactor-1 (INI1) test to see if you have a rare STS called epithelioid sarcoma (ES). (See sidebar for more on ES.)
Learning More About Epithelioid Sarcoma
A rare type of STS, epithelioid sarcoma (ES) accounts for less than 1% of all STS, which themselves account for approximately 1% of all cancers, according to research published in “Archives of Pathology & Laboratory Medicine.” ES can present as a lump or sore on the skin.
Notably, more than 90% of ES tumors do not express the INI1 protein, which when present acts to suppress tumor growth. INI1 loss plays an important role in the diagnosis of ES, according to researchers with “The American Journal of Surgical Pathology.”
Data from the NCI indicates that approximately 150-200 people in the United States are diagnosed with ES each year. Research published in “The Journal of Clinical and Aesthetic Dermatology” found the disease often occurs in young adults in their 20s and 30s. Because most ES patients are adolescents and young adults, there is a gap in the unique psycho-social needs for this patient population, including resources for patients who miss school while undergoing treatments, as well as fertility considerations later in life.
If you or someone you love is living with ES, you can find resources, information and the real-life perspective of an ES survivor at ESsentialsforES.com.
Content courtesy of Epizyme, Inc.
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For the up to 16 million Americans living with IBS-D, it is often an uncomfortable disorder that can reduce a patient’s quality of life. IBS-D affects twice as many women as men and often occurs in people younger than 45. It can cause interference with daily activities and avoidance of certain foods. If you’ve experienced these symptoms, Dr. Howard Franklin, MBA, vice president of medical affairs and strategy at Salix Pharmaceuticals. offers two important steps you can take.
(BPT) - "As a doctor, I want patients to have open conversations with me about any symptoms they may experience without feeling uncomfortable," said Dr. Howard Franklin, MBA, vice president of medical affairs and strategy at Salix Pharmaceuticals. "But, I understand that patients may sometimes choose not to talk about symptoms they find embarrassing."
Such is the case when it comes to discussing bowel movements. For people who experience abdominal pain and diarrhea, it is important to discuss these symptoms with your doctor as they may be signs of irritable bowel syndrome with diarrhea (IBS-D).
A report published by the American Journal of Gastroenterology found that up to 75 percent of individuals living with irritable bowel syndrome may be undiagnosed. You are not alone.
For the up to 16 million Americans living with IBS-D, it is often an uncomfortable disorder that can reduce a patient’s quality of life. IBS-D affects twice as many women as men and often occurs in people younger than 45. It can cause interference with daily activities and avoidance of certain foods.
If you’ve experienced these symptoms, Franklin offers two important steps you can take.
Understand the disorder
IBS-D is a disorder of the large intestine and though the precise cause is unknown, it is believed that there are various factors that can play a role in creating symptoms. Stronger, longer muscle contractions in the intestines and poorly coordinated signals between the brain and the intestines are all possible causes for IBS-D. Often, IBS-D is triggered by food, caffeine, stress, carbonated drinks, artificial sugars or infectious diarrhea.
Changes in bacteria in the gut have also been linked to symptoms of IBS-D. In a healthy state, the microbiome and the human host have a mutually beneficial relationship as the host intestine provides the bacteria with an environment to flourish and the bacteria provides physiological stability. A change in the number of bacteria and in their type can disrupt this relationship.
Talk to your doctor
Don’t hesitate to initiate the conversation with your doctor if you experience symptoms of IBS-D.
It’s time to talk to your doctor if:
* Your abdominal pain keeps coming back at least one day per week in the last three months
* The frequency of your bowel movements, and/or the way your stool looks has changed
Here are a few ways you can prepare for a conversation with your doctor:
1. Write down your symptoms and triggers.
2. Make a list of all your medications.
3. Plan questions in advance, such as: What are the likely causes of my symptoms? Should I make any changes to my diet or lifestyle? What treatment options do you recommend for me?
There is no need to suffer with IBS-D in silence. Speak up to your doctor and, together, find ways to manage the disorder. For more information about IBS-D, visit www.LetsTalk-2.com.
(BPT) - Each year, more people die of lung cancer than any other form of cancer — more than colon, breast and prostate cancers combined. The American Cancer Society estimates of the 224,000 new cases of lung cancer diagnosed each year, 155,000 will succumb to the disease.
Many have heard the statistics about lung cancer, but for those who have lived through it, or who have a friend or loved one battling the disease, these numbers are even more personal and frightening. The low five-year survival rate (five to 14 percent) for late-stage lung cancer patients makes the search for a way to treat this deadly disease all the more urgent.
To beat cancer, early detection is critical. Scientific research over the past several decades has revealed that cancer is a disease primarily caused by changes — or mutations — in the genes. This discovery has led to a major shift in how early cancer can be detected and treated. Now, researchers are able to identify mutations in the genetic code that are most likely to cause potentially deadly cancers. This has led to the development of new testing technology and drugs that target those specific mutations.
This approach is in stark contrast to traditional detection methods that are limited in their ability to test for a small number of specific mutations linked to only one possible treatment. This painstakingly long process can take several weeks to identify an effective treatment.
In a matter of days, modern techniques using next-generation sequencing technology can save valuable time by avoiding the need to run multiple tests by simultaneously screening tumor samples for multiple mutations and multiple potential therapies. The new technology also reduces the likelihood of subjecting patients to unnecessary and invasive secondary biopsy procedures.
New advancements in early detection and treatment
The U.S. Food and Drug Administration (FDA) recently approved the Oncomine(TM) Dx Target Test, a first-of-its-kind genetic screening solution that can detect multiple gene mutations associated with non-small cell lung cancer (NSCLC) from a single tissue sample. The test has also been approved to aid in selecting which specific FDA-approved NSCLC treatment the patient may be eligible for.
Take action and talk to your doctor
A recent survey by the Journal of Precision Medicine showed that only about a third of patients and caregivers had a good understanding of genomic tools for cancer detection. That’s why talking to a doctor, loved ones and others about new techniques like sequencing-based tests to help inform more effective treatment options is important. Doctors and healthcare networks have a responsibility to their patients to provide the most effective innovations so patients receive the best care possible.
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