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The Rarest of the Rare

1/24/2019

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There is little information available about epithelioid sarcoma. Patients, advocates, doctors and researchers across the United States are aiming to educate people about this ultra-rare cancer and the unmet need for an effective, tumor-specific treatment. Consider these facts about ES.


The Rarest of the Rare

What to know about a cancer you may not have heard of

(Family Features) A woman celebrating her 40th birthday, a young boy starting second grade or a college grad about to begin his career. All three could develop a rare form of cancer known as epithelioid sarcoma (ES), a form of soft-tissue sarcoma.

There is little information available about ES. Patients, advocates, doctors and researchers across the United States are aiming to educate people about this ultra-rare cancer and the unmet need for an effective, tumor-specific treatment. Consider these facts about ES:

What are Soft-Tissue Sarcomas and What is Epithelioid Sarcoma?
Soft-tissue sarcomas (STS) are a type of cancer that occur in tissue like muscle, fat, skin, nerves and blood vessels. There are more than 50 types of STS, including ES, which is a rare form that can occur under the skin in the limbs (such as the arms, hands, legs or feet) or soft tissue in other places like the abdomen. Adults in their 20s and 30s and men, in particular, are more likely to get ES, although it can affect people of all ages and genders, according to research published in the Journal of Clinical and Aesthetic Dermatology.

How Rare is Rare?

According to the American Cancer Society, a rare cancer is defined as fewer than six new diagnoses per 100,000 people per year.

ES is an ultra-rare cancer. According to available epidemiology and case reports, it is estimated about 600 people are properly diagnosed in the U.S. and Europe each year.

What are the Most Common Types of ES and How Do They Impact Diagnosis?
ES can take two forms:
Distal-type: Classic form, typically affects teenagers and young adults.

  • Typically forms under the skin in areas like hands, legs and feet.
  • Can be mistaken for another skin condition like an infected wart or a wound that won’t heal, which may delay diagnosis.
  • Proximal-type: Rarer form, mainly affects adults and is more aggressive.
  • Typically forms in central areas of the body like the abdomen.
  • Can be mistaken for menstrual cramps or an upset stomach, making identification and diagnosis more difficult.

Dealing with a Diagnosis?
Due to its rarity, harmless appearance in its initial stages and occurrence in young people, ES is often misdiagnosed, according to the Liddy Shriver Sarcoma Initiative. For this reason, the Sarcoma Foundation of America recommends checking often for lumps and bumps in places they shouldn’t be.

For people faced with a sarcoma diagnosis, it’s important to get a second opinion from a sarcoma specialist. These specialists have extensive knowledge of STS and can determine what form of sarcoma one may have, what stage it is and the best course of treatment. The specialist may confirm the diagnosis with a physical examination, a scan or a tissue sample (biopsy) of the area.

It’s common to feel a range of emotions after a diagnosis of ES, according to Clear View Health Partners, including:

  • Fear
  • Denial
  • Frustration
  • Anxiety
  • Hope that treatment will be successful
  • Determination to beat ES

What Treatment Options are Available?
Treatment options depend on a variety of factors, including the location of the tumor, tumor staging and whether the disease has metastasized or spread to other parts of the body.

For patients with early stage ES, many elect to have surgery to remove the tumor, which may precede or be followed by radiation therapy or chemotherapy treatment, according to the Journal of Clinical and Aesthetic Dermatology. If the cancer returns or spreads, a patient may undergo radiation therapy and chemotherapy. New treatment options are being studied through clinical research, which is why seeking a specialist in the field is important if one is faced with a diagnosis.

As with many cancers, early detection is important and can increase survival or successful treatment. Typically, the distal form of ES is associated with more favorable survival rates than the proximal form.

4 Things to Do to Address ES Today

1. Don’t ignore your bumps and lumps, see a doctor as soon as possible.

  • curesarcoma.org/patient-resources/sarcoma-infographic/  

2. Learn more about epithelioid sarcoma and its symptoms.

  • mayoclinic.org/diseases-conditions/epithelioid-sarcoma/cdc-20392420

3. Seek a second opinion.

  • sarctrials.org/sarc-centers-map

4. Find support if you’re faced with a diagnosis.

  • sarcomaalliance.org/resources/support-groups
  • cancersupportcommunity.org
  • cancercare.org/counseling

An ES Diagnosis Journey

In the spring of 2008, Maria Voermans’ 4-year-old daughter requested an “airplane ride,” and as Voermans lifted the young girl up with her legs, she had to make an “emergency landing” because of some sudden and significant pain in her upper right thigh.

After a few months, the pain persisted. Voermans continued to jog and play sand volleyball, thinking nothing of it. At the recommendation of her primary care physician, she took some anti-inflammatories and tried to rest, which wasn’t easy to do as a single mother of two young children.

Two more months went by and her leg caused increasing problems. She could feel something in her leg, but never considered it a “lump” because it was not visible on the outside. Voermans took matters into her own hands and visited a sports medicine orthopedic specialist for further testing.

An MRI found a mass in her right leg and she was referred to one of the few musculoskeletal oncologists in Wisconsin, her home state. He ordered a biopsy, which on Voermans’ youngest daughter’s third birthday confirmed her worst fear: it was a rare form of cancer called proximal-type epithelioid sarcoma, and it was stage three. Her biggest concern was not living to experience future holidays, birthdays, graduations and other life milestones with her daughters.

Voermans underwent chemotherapy, radiation therapy and had surgery to remove the tumor. As of July 2018, Voermans reports the cancer has not returned.

Today, she’s a wellness coordinator supporting other people diagnosed with cancer who are undergoing treatment or post-treatment. She’s able to use her own cancer journey to provide empathy to others, and it’s brought satisfaction to the whole experience.

Content courtesy of Epizyme, Inc.

Photo courtesy of Getty Images (Doctor talking to man)

SOURCE:
Epizyme, Inc.

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Don't let the summer sun blind you to this lesser-known skin cancer

7/6/2018

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Don't_let_the_summer sun blind_you_to_this_lesser-known_skin_cancer
Don't let the summer sun blind you to this lesser-known skin cancer

Melanoma is a skin cancer many of us are familiar with. But have you heard of a skin cancer called cutaneous squamous cell carcinoma (CSCC)? If not, you might be surprised to learn that CSCC is actually one of the most common skin cancers in the world – even more common than melanoma with an estimated 700,000 new cases diagnosed in the U.S. annually. CSCC can also be a deadly skin cancer. Every year, an estimated 7,000 people in the U.S. die of CSCC.



(BPT) - Most of us look forward to the balmy breezes and cheerful sunshine brought about by spring and summer, especially those of us living in climates where winter is long, gloomy and bitterly cold. Yet as we get our shorts, polo shirts and swimsuits out of storage, it’s important to remind ourselves to stay sun smart and vigilant against skin cancer.

Melanoma is a skin cancer many of us are familiar with. But have you heard of a skin cancer called cutaneous squamous cell carcinoma (CSCC)? If not, you might be surprised to learn that CSCC is actually one of the most common skin cancers in the world – even more common than melanoma with an estimated 700,000 new cases diagnosed in the U.S. annually.

CSCC can also be a deadly skin cancer. Every year, an estimated 7,000 people in the U.S. die of CSCC. And in the southern part of the U.S., the number of deaths from CSCC may actually be higher than deaths from melanoma.

“The good news is that CSCC is usually highly treatable when detected early,” notes Dr. Sunandana Chandra, a medical oncologist at the Robert H. Lurie Comprehensive Cancer Center Northwestern University. “That’s why it is important to know about CSCC, so you can take the necessary precautions to protect yourself, know how to identify early signs of the cancer, and to understand your treatment options if it progresses. Being vigilant about your skin and reaching out to your doctor early with any concerns will allow you to consider more treatment options and possibly have better outcomes.”

So what do you need to know about CSCC? Here are three important tips:
  1. Take a Closer Look at Your Skin. Since early detection is key, it’s important to know your skin and what to look for. As a precaution, the Skin Cancer Foundation recommends that adults check their skin monthly and schedule an annual dermatologist visit for a full-body skin exam. CSCC typically appears on sun-exposed parts of the body, such as the face, head and neck, and can take several forms, including rough or scaly red patches, raised lumps, open sores or wart-like growths. If you notice an unusual spot on your skin, be sure to schedule an appointment with your doctor immediately.

  2. Know the Stats, Know Your Risk. Exposure to harmful UV rays is the main cause of CSCC, but there are also certain groups of people who are at higher risk. Men are three times more likely than women to be diagnosed with CSCC, and the cancer tends to occur more frequently in elderly patients ages 65 and older. Also, those living in the southern parts of the U.S. should be particularly thoughtful about how much sun exposure they are getting.

  3. Involve Your Doctors and Ask the Right Questions. If you think you have CSCC, don’t wait. Talk to your doctor right away. Often CSCC can be easily cured in its early stages with the help of a dermatologist or Mohs surgeon. However, if the CSCC progresses and grows bigger or spreads, a multidisciplinary team of healthcare providers may be needed to help assess the situation and work with you to figure out your options. This team may include your original dermatologist or Mohs surgeon plus additional physicians and surgeons from other specialties. Good questions to ask your healthcare team when it comes to CSCC include: What treatment options can I consider, and how do they work? What are the side effects of these treatments? What results can I expect from these treatment options? Are there any advances in CSCC treatment to be aware of? What other options may I consider (e.g., clinical trials)?

If you think you or someone you know may have CSCC, contact a doctor and visit SkinCancer.org.


KEYWORDS


  • American Cancer Society ×
  • BPT ×
  • Brandpoint Content ×
  • cancer ×
  • clinical trials) ×
  • dermatology ×
  • detection ×
  • diagnosis ×
  • doctors ×
  • early detection ×
  • medical research ×
  • melanoma ×
  • mortality ×
  • oncologists ×
  • oncology ×
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A springtime glow: 6 ways to purify your skin

5/2/2016

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(BPT) - You've heard of detox diets and ridding your body of toxins, but did you know the same is possible for your skin? Environmental toxins and pollutants not only cause breakouts, but also bring out a dull, less vibrant looking complexion.


"Stressors from your environment and lifestyle can cause redness, irritations and premature aging," says Claire Larsen, skin category manager for LifeSpa at Life Time Fitness. "Proper skincare goes beyond simply washing your face before you go to bed. Detoxing your skin can help prevent oily and itchy skin, and even age spots and wrinkles."


Larsen offers her expert tips for detoxifying your skin and flaunting a natural glow year round:


1. Cut out acne causing foods.

Often, what you eat will show up on your face and body. Forehead breakouts are usually due to eating foods your body has trouble breaking down, like refined sugars, carbs, wheat and dairy. Between the brow breakouts are linked to the liver, so try cutting down on alcohol and fatty foods, and adding in liver supporting herbs such as dandelion root, milk thistle seed or yellow dock root. No matter what you do, always be sure to drink plenty of water throughout the day.


2. Identify hormone imbalances.

Track the timing, location, shape, size and sensation of your breakouts. Hormonal acne tends to flare up at predictable times and is likely located beneath the cheekbones and along the jawline. It's also typically deep, cystic and sensitive. Talk to your dermatologist or health care provider if you think you might have hormonal related breakouts.


3. Notice how your routine affects your skin.
Are you noticing temple breakouts? It could be from the products in your hair. Make sure you're thoroughly cleansing your face each morning and night, making sure to concentrate on your hair line. It's also important to regularly change your sheets and pillowcases. Studies show you should wash your bedding once every week.


4. Use detoxifying products.
Serums with vitamins C and E, like Vivierskin(R) CE Peptides Serum, help to neutralize free radicals before they can damage the collagen and elastin in your skin. Products with antioxidants will fight against the toxins and pollutants your skin faces every day. Additionally, a detoxing bath containing Epsom salt, like mio's Liquid Yoga Bath Soak, will help to clean out your pores.


5. Try a skin detox treatment.
When your skin feels like it needs some extra TLC, head to the spa for a HydraFacialMD(R). LifeSpa's HydraFacial service deep cleans with vortex extractions and a mild chemical peel while also infusing lots of hydration. A lymphatic drainage can be added for a special focus on detoxification and an LED light treatment can also help with the clarity and smoothness of your skin.


6. Get your sweat on.
When you get your heart beating and your skin sweating, it's easier for your body to release toxins. Try to work up a sweat at least three days a week. You could even consider trying out a hot yoga class or heated spa session to encourage the sweat beads to fall.


If you notice a problem with your skin, a detox may be just the solution you've been searching for. Try these tips to purify your skin so you can radiate confidence, or book an appointment online or at your local LifeSpa, the nation's largest spa operator, for a personalized skin analysis with a certified esthetician.


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Protect Your Family During Summer Fun

5/1/2016

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Whether you’re planning outdoor fun for your backyard, a local park or the open wilderness, portable generators can take your outdoor recreation and summer fun to the next level, but their exhaust fumes can pose serious risks. So before you head out to enjoy a fun summer day, make sure you’re ready to protect your family from the potential dangers associated with portable generator use with these tips.


Protect Your Family During Summer Fun

(Family Features) Summer is the perfect time for outdoor recreational activities, from ballpark tailgates and camping trips to backyard barbecues or simply hosting a party outside. Portable generators can be used to make these activities even more enjoyable, but their exhaust fumes can pose serious risks. So before you head out to enjoy a fun summer day, make sure you’re ready to protect your family from the potential dangers associated with portable generator use.

Whether you’re planning outdoor fun for your backyard, a local park or the open wilderness, portable generators can take your outdoor recreation and summer fun to the next level. Portable generators make it possible to cook, use a cooling fan, play festive music, power a karaoke machine or even light up a string of twinkling lights to help set the stage for a great time.

“Some of our most beloved summer traditions can be even more enjoyable with electricity from a portable generator, but there are some notable risks,” said Susan Orenga, representative for the Portable Generator Manufacturers’ Association (PGMA). “Proper handling and taking the appropriate safety precautions can help ensure that users fully appreciate the benefits of portable power.”

The most serious risk comes from exhaust fumes containing carbon monoxide, a gas you cannot smell, see or taste. Excess exposure can have fatal consequences for both people and animals.

This summer, portable generators will be used for a variety of applications, providing a convenient, flexible energy source that is easily transportable. Taking proper safety precautions will help ensure you can enjoy the many benefits and capabilities of portable generator use without putting yourself or others in danger.

Before you use a portable generator to power up your summer activities, keep these safety tips from PGMA top of mind:

  • To avoid dangerous carbon monoxide accumulation, always “Take It Outside.” Never run a portable generator indoors or in partially enclosed spaces, including garages, porches, campers or tents.
  • Always place a portable generator downwind and point the engine exhaust away from occupied spaces, such as a campsite, tailgate or seating area.
  • If you feel sick, dizzy or weak while using your portable generator, get to fresh air immediately and call 911 for emergency medical attention.
  • Install a battery-operated carbon monoxide alarm according to manufacturer’s instructions.
  • Always refer to the generator’s owner manual for further information about safe operation and potential hazards.

Learn more about safely operating portable generators this summer at pgmaonline.com and takeyourgeneratoroutside.com. 

Photo courtesy of Getty Images

SOURCE:
Portable Generator Manufacturers' Association

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Step up your summer beauty regimen with help from expert dermatologists

4/25/2016

 
Picture


(BPT) - While magazines make summer beauty look simple, in reality it's anything but. From bloat to breakouts, summer is wrought with beauty challenges.

The experts at the Mayo Clinic offer advice on eight of the most common beauty and health concerns of summer.

1. Maintaining a healthy (natural) glow

While tanning beds offer a quick-fix to achieving a golden glow, they also cause exposure to damaging UV radiation which can cause premature aging as well as increase the risk of skin cancer. If you'd like a sun-kissed glow without the risk, consider using a sunless tanning product. Whether in the form of a lotion, spray or done as a professional service at a salon, sunless tanning offers a safe alternative to both tanning beds and sunbathing.

2. Ingrown hairs


Swimsuit season often means shaving more frequently, which can result in painful and unsightly ingrown hairs. These hairs grow out of the skin slightly and then curl back underneath the skin. To avoid ingrown hair, use a lubricating shave gel followed by a sharp, single-blade razor. Shave in the direction of hair growth and avoid pulling the skin taut.

3. Sunburn


It's easy to get lost in the fun of the summer sun. Avoid sunburn by dressing in light layers and using a broad-spectrum sunscreen with an SPF of at least 15. Remember, sunscreen generally stays at original strength for three years. If you do get sunburn, take a cool bath or apply a clean towel dampened with cool tap water. Then apply moisturizer, aloe vera lotion or gel or a low-dose hydrocortisone cream.

4. Bloat


Ice cream, hot dogs and fried goodies are cornerstones of traditional summer festivals. Unfortunately, too much of these types of foods can leave you feeling bloated and sluggish. Fight bloat by eating fresh foods grown locally, such as carrots, tomatoes, melons and berries. Want a healthier cool treat? Try freezing grapes for a no-guilt sweet dessert.

5. Cracked nails


Pool chemicals, hot sun, gardening and building sand castles can all cause cracked nails. To protect nails, keep fingernails dry, clean and rub moisturizer into the nail beds and cuticles. Consider applying a nail hardener to add a protective layer against summer elements. If brittle nails persist, ask your doctor about biotin, a nutritional supplement that may help strengthen weak fingernails.

6. Healthy, hydrated skin


Staying hydrated is a summer must, but skin hydration isn't as simple as drinking water. Dehydrated skin feels rough and loses elasticity. To maintain proper hydration, avoid prolonged exposure to dry air or chlorinated water. When bathing, use a gentle cleanser instead of soap and avoid using skin care products that contain alcohol. Moisturize immediately after cleansing. Also try incorporating antioxidant-rich foods into your diet such as spinach, blueberries or salmon.

7. Acne


Sunshine and heat can cause the body to sweat. This combo clogs pores and can lead to acne. Some chemical treatments can leave the skin more sun-sensitive, so natural treatments such as tea tree oil, azelaic acid and even green tea extract are a smart choice in reducing inflammation. Another potential cause for acne can be outdated cosmetics. Make sure the products you use are kept clean to avoid bacterial buildup and avoid using them past their expiration date - six months is a good rule of thumb.

8. Beautiful legs


From swimsuits to shorts, summer is the time most people show off their legs. This can be uncomfortable for some when faced with common leg woes such as spider veins and varicose veins. Several options are available to combat these issues which range from sclerotherapy and laser surgery, to more advanced techniques such as vein-stripping. To learn more, visit mayoclinic.org to find out what treatment is best for you.

To discuss these and any other persistent skin or summer-related health concerns, make an appointment with Mayo Clinic Dermatology today.


KEYWORDS

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  • beauty ×
  • dermatology ×
  • hair ×
  • hands ×
  • lips ×
  • Mayo Clinic ×
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  • nails ×
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A personalized approach to treating metastatic melanoma

2/5/2016

 
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(BPT) - “You have melanoma.” For many people who hear these words, a deeply personal health journey follows. But one of the most important facts patients and caregivers may learn is that melanoma is not a single disease. It can vary from person to person, often due to genetic changes that are unique to each patient. Doctors use this information to select an appropriate treatment.
If detected early, melanoma is almost always treatable. But if left untreated, it can spread from its original location to other parts of the body, leading to a condition known as metastatic melanoma. At this advanced stage, it is the most serious and life-threatening form of skin cancer. However, recent research has given hope to people living with metastatic melanoma. Certain patients have responded well to personalized therapies, which are treatments tailored to the characteristics of a person’s disease.

One of the most common causes of melanoma is damage that occurs to the DNA in skin cells, often due to exposure to ultraviolet light. This damage to the DNA (also called a gene mutation) can cause cancerous tumors to form in the skin. It’s important to know that since no two melanoma tumors are the same, selecting a treatment based on specific disease traits can be crucial. A doctor can perform certain tests to determine the specific type of melanoma that a person has.

Research has shown that a gene inside cells known as BRAF (pronounced “B-RAF”) plays a significant role in the growth of many melanoma tumors. In about half of all metastatic melanoma cases, the BRAF gene is changed (or mutated) and causes cancer cells to quickly grow and multiply. This type of melanoma is called “BRAF positive.” Using a small piece of the melanoma tumor, a gene test can identify whether BRAF mutations are present, providing doctors more information about the cancer. This information can help doctors determine an appropriate treatment.

In recent years, medicines that target BRAF mutations have become available to treat patients living with BRAF-positive metastatic melanoma.

To learn more about treatment options for metastatic melanoma, talk to your doctor and visit www.novartisoncology.com.

Melanoma by the Numbers
* More than 200,000 people worldwide were diagnosed with melanoma in 2012.
* Melanoma will cause about 10,000 deaths in the US this year.
* 62 years is the average age of a person newly diagnosed with melanoma.
* About 50 percent of all patients with metastatic melanoma have changes in the BRAF gene and may be candidates for targeted therapies.
* One treatment may not be appropriate for all types of melanoma.




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